Salmonella genome

Biological and genetic basis of epidemiological competitions between Salmonella Enteritidis and S. Infantis

Project ID
NKFI K 128600
Project leader
Period
2018 - 2022

Majority of human non-typhoidal salmonellosis is still being caused by S. Enteritidis (SE), but S. Infantis (SI) is the major cause of broiler-associated human infections. However the prevalence of SI in humans is far less high than expected based on its high prevalence in broilers. This could indicate its presently lower infectivity for human, which however could turn to be a more serious global public health concern by the acquisition of new virulence/antibiotic resistance properties.

The overall goal of the proposed research is to explore biological, epidemiological and genetic differences between SE and SI in order to understand factors influencing their differing prevalence in broilers and in humans in Hungary.

We aim to reveal diversity of resistance/virulence properties, and to study the exchanges of multiresistance/virulence plasmids between Salmonella and E. coli in influencing persistence and environmental survival in vivo/in vitro or on flock levels “in toto”.

The most interesting point is the understanding of the epidemiologic and molecular interactions between SE and SI, which could also be supported by modeling horizontal gene transfers between these serovars and E. coli in the mammalian and avian intestine.

Our expected results could open a new perspective in the epidemiology of SI, and we could hope to solidify our position between the cutting edge research competitors working under the “One Health” concept.

Further collaborators
Béla Nagy Dr., member of the Hungarian Academy of Sciences

Czékmán Renáta, laboratory technician
Szalai Ninetta, MSc student, ELTE

Levente Emődy, Prof. emeritus, Department of Medical Microbiology and Immunology, University of Pécs, Pécs
Dóra Szabó, Professor and Head of Institute of Medical Microbiology, Semmelweis University, Budapest
Béla Kocsis, Associate Professor, Institute of Medical Microbiology, Semmelweis University, Budapest
Erzsébet Adrián, Head of Salmonella Reference Laboratory, National Food Chain Safety Office, Food and Feed Safety Directorate, Budapest
Szilárd Jánosi, Head of Bacteriology, Veterinary Diagnostic Directorate, National Food Chain Safety Office, Budapest
Judit Pászti, National Public Health Center, Budapest